07 Jul

Essential Information to Keep in Mind

In recent years, fasting has gained popularity among various groups of individuals. Some individuals have found it to be an effective weight loss method, while others see it as a means to enhance their overall health and longevity. 

Research has shown that fasting is associated with a reduced risk of diabetes, improved cardiovascular well-being, enhanced cognitive function, weight loss, and more. 

However, for individuals accustomed to consuming three meals a day, the idea of fasting can seem overwhelming. Fortunately, there may be an alternative for those who struggle with traditional fasting methods: the fasting-mimicking diet.

What is this FMD ?

The fasting-mimicking diet (FMD) is a modified fasting approach that differs from a traditional fast. Instead of completely abstaining from food, as in a conventional fast, the FMD involves consuming small portions of nutrient-dense food.

Typically lasting for a period of five days, emerging research suggests that the FMD can offer the same health benefits as fasting while still allowing for some food intake. 

The FMD was pioneered by Valter Longo, PhD, a biogerontologist and cell biologist at the University of California, Los Angeles (UCLA). By incorporating calorie restriction, the FMD aims to replicate the physiological effects of fasting, while still providing essential nutrients. When done correctly, calorie restriction has shown potential in extending lifespan and reducing the risk of age-related diseases.

Contrasting the Fasting-Mimicking Diet with Intermittent Fasting

The Distinction Between the Fasting-Mimicking Diet and Intermittent Fasting The fasting-mimicking diet (FMD) and intermittent fasting (IF) diverge in their approaches. 

While the FMD permits the consumption of small quantities of food throughout the day, ensuring specific amounts of carbohydrates, fats, and protein, intermittent fasting involves complete abstinence from food for a designated period. 

During the eating window in IF, there are typically no dietary restrictions. While both FMD and IF offer numerous health benefits, opting for minimally processed foods instead of unhealthy ultra-processed foods can significantly enhance the advantages derived from intermittent fasting. Minimally processed foods are generally richer in fiber and nutrients, promoting greater satiety.

Did you know? Throughout history, fasting has been practiced safely for religious, cultural, and health reasons.

A fasting-mimicking diet allows individuals to consume small portions of nutrient-dense food while still reaping the health benefits associated with more traditional fasting methods.

Exploring the Fasting-Mimicking Diet Meal Plan

During the Fasting-Mimicking Diet (FMD), typically lasting five days, you adhere to a low-calorie and low-protein meal plan before returning to your regular eating pattern for the remainder of the month/quarter. 

You have the option to do the FMD once or repeat it on a monthly basis for up to six months. The FMD incorporates specific macro- and micronutrient proportions. 

Each day's meal plan consists of:

•     43 to 47% carbohydrates

•     44 to 46% fats

•     9 to 11% proteins

On the first day, the calorie intake is approximately 1,100, while days two through five provide around 725 calories per day.

Currently, there is a pre-packaged FMD diet available, developed by Dr. Longo, which eliminates the need for meal planning. It is plant-based and excludes gluten, GMOs, and animal products. 

Here is a link to some meal plan recipes so you won't need to buy the meals.

The package includes soups, bars, snacks, teas, supplements, and a glycerol solution to help preserve lean muscle mass while keeping the body in a fasting state. 

While this option offers precise nutrition from whole foods, it may be possible to replicate the benefits of the commercial FMD by following the macronutrient recommendations and dietary principles of the pre-packaged kit. 

However, it's important to note that a "fasting-mimicking diet do-it-yourself" approach has not been clinically studied and should only be undertaken under the recommendation and supervision of an integrative healthcare professional to ensure safety and effectiveness.

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Exploring the 6 Health Benefits of a Fasting-Mimicking Diet:  


Autoimmune Disease: 

Autoimmunity, where the immune system attacks the body's own cells and tissues, is increasing in the United States. 

Research published in the journal Arthritis and Rheumatology indicates that the nutrients in a fasting-mimicking diet (FMD) can influence immune cells called lymphocytes, potentially benefiting autoimmune conditions such as multiple sclerosis (MS), rheumatoid arthritis (RA), and type 1 diabetes. 

Animal studies have shown that the FMD can reduce the severity of MS, increase corticosterone and regulatory T-cell levels, reduce inflammation, and improve nerve function.

Brain Health: 

Animal studies suggest that a fasting-mimicking diet could stimulate the formation of new brain cells, contributing to improved cognition, motor learning, and memory. 

Further research is needed to confirm these findings for humans, especially for older individuals.

Type 2 Diabetes:

Practicing the FMD for three consecutive months has shown promise in reducing visceral fat, improving glucose metabolism, and enhancing insulin sensitivity in individuals with type 2 diabetes. 

Additional research is required to investigate the benefits of combining the FMD with exercise and other healthy lifestyle changes for preventing and managing type 2 diabetes.

Heart Disease: 

The FMD may help reduce risk factors associated with cardiovascular disease. 

A study involving 100 participants found that practicing the FMD monthly for three months resulted in lower blood pressure, LDL (bad) cholesterol, total cholesterol, triglycerides, and C-reactive protein (a marker of inflammation). 

Waist circumference, an important risk factor for heart disease, also improved during the trial.


Practicing the FMD regularly has shown potential to extend health span and lifespan by reducing IGF-1 levels, oxidative damage, and inflammation, while optimizing energy metabolism and promoting cellular protection in animal studies. 

The FMD's restriction of protein intake has been linked to increased health and longevity. Additionally, the FMD may induce autophagy, the body's process of cellular rejuvenation.

Weight Loss: 

The FMD has been found to aid in weight loss by reducing body weight, total body fat, and waist circumference. It may also increase lean body mass, with effects persisting even after completing the three-month FMD program.

Side Effects: 

Temporary side effects of the FMD may include dizziness, fatigue, headache, hunger, sugar cravings, and weakness.


The FMD is generally safe for most individuals and may provide several health benefits. However, its effectiveness compared to other methods of intermittent fasting is still uncertain. 

The FMD is not recommended for individuals with eating disorders, those under the age of 18, and pregnant or breastfeeding women.

It is important to consult with a healthcare professional before starting the FMD or any significant dietary changes.

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FMD - summary and conclusion

The fasting-mimicking diet (FMD) offers a modified fasting approach that allows for the consumption of small amounts of food while still reaping the benefits of fasting. It has the potential to promote healthy aging, weight loss, and improvements in cardiovascular, cognitive, immune, and metabolic health. 

The FMD provides a simple and effective alternative to time-restricted eating or other conventional fasting methods. 

However, further research is necessary to validate many of the suggested health benefits associated with the FMD. 

Before embarking on a fasting-mimicking diet or any significant dietary changes such as intermittent fasting or time-restricted eating, it is recommended to consult with your healthcare practitioner, particularly if you have an existing medical condition.

Remember, your healthcare professional can provide personalized guidance and ensure the suitability and safety of such dietary approaches.